John Drummond was born in Savannah-la-Mar, Jamaica, in 1744. He received an MD from the University of St Andrews in 1786 and served as surgeon to the 55th Regiment of Foot from 1784 to 1802. A plantation owner and slaveholder, Drummond was the subject of an Act of Parliament affording his mixed-race children the same legal rights as English subjects born of white parents. Drummond died in Jamaica in 1804.

Patrick Baron Seton earned his MD from the University of Edinburgh with a thesis on paralysis. A member of the prominent Scotto-Swedish Seton family, he was born in Linlithgow but spent much of his life living outside Stockholm at the family seat of Ekolsund Castle. He died in Torquay, Devon, in 1837.

William Spink was born in Dundee in 1746, the son of Andrew Spink, a tobacco smuggler. After earning his MD from St Andrews he joined the East India Company, working as a ship's surgeon before settling in Bombay, now Mumbai, where he lived until his death in 1798.

Charles Stuart was born in 1745 in Fife, the son of James Stuart, the future Lord Provost of Edinburgh. Stuart's initial career was as a minister; however after losing faith with the Church of Scotland he trained as a doctor. Earning his MD from the University of Edinburgh with a thesis on the nervous system, he established a medical practice on Nicolson Street. Stuart held a number of roles in the College, including Elector and Fiscal Officer, before serving as President of this College from 1806 to 1809. He was also a co-founder of the Royal Society of Edinburgh. Stuart died in 1826 in Edinburgh.

Alexander Hamilton trained initially as a surgeon, joining the Royal College of Surgeons of Edinburgh in 1751 and serving as its president from 1776 to 1778. After lecturing in midwifery at the University of Edinburgh alongside James Young, he became Professor of Midwifery in 1783, the same year he was awarded an MD by the University of St Andrews. Hamilton served as Professor until 1800, when he retired in favour of his son James Hamilton, who would also later serve as President of this College. The two men co-founded the Edinburgh Lying-In Hospital, which would later become the Simpson Memorial Hospital. Hamilton died in 1802.

Alexander Grant Clugston was born in Stranraer in 1747. In 1768 he joined the East India Trading Company as a ship's surgeon. After serving on board various ships of the company he was furloughed from 1787 to 1790. During this period he was awarded an MD by the University of St Andrews and became a Fellow of this College. Returning to India, he became Surgeon General of the EITC in Bombay, now Mumbai, until his death in 1792.

John Craigie was born in 1748. He joined the Indian Medical Service in 1772 as an Assistant Surgeon, rising to the rank of Surgeon in 1780. He was awarded an MD by Marischal College in 1788, and became a Fellow of this College in 1789. He died onboard a ship returning to Europe in 1795. His wife, Jacoba Helena van As was a descendent of the first enslaved woman in the Dutch Cape, and a number of their children entered the Indian military or civil services.

Charles Webster, born in Scotland circa 1750, received an MD from the University of Edinburgh with a dissertation on the balance of blood vessels. By 1779 he was physician to the Edinburgh Public Dispensary, where he also taught chemistry. A Fellow of this College from 1789, he later became a Licentiate of the Royal College of Physicians of London (1795) and an international member of the Royal Academy of Medicine of Paris. His works included an eight-volume history of the Dispensary and a life of Archibald Pitcairne. He died in 1795.

William Wright was born in March 1735 in Perthshire. After early schooling in Crieff, Wright was apprenticed to a local surgeon in Falkirk. In 1756, Wright attended medical lectures at Edinburgh University, but did not obtain a degree. In 1757, he sailed to Greenland as a ship's surgeon on a whaler. In January 1758, Wright presented himself for examination at the Royal College of Surgeons of Edinburgh and was subsequently appointed surgeon's mate on a Royal Navy warship. Late in 1759 he was promoted to surgeon's first mate. He remained in service in the West Indies until the end of the Seven Years' War. Wright accepted the position of regimental surgeon to the Jamaican regiment, although he was captured and made a prisoner of war in Spain. Wright escaped and returned to England in 1780 before returning again to Jamaica, where he would stay from 1782 to 1785. Wright became physician to the army and director of military hospitals in Barbados from 1796 to 1798. Wright never married, but adopted his nephew whom he trained in the medical profession. He died in Edinburgh on 19 September 1819.

Thomas Gillespie received his medical degree from Marischal College, Aberdeen, and began practice in Ayrshire, where he treated the dying 9th Earl of Cassillis. He later moved to Edinburgh. His son Alexander and grandson James Donaldson were surgeons and both became Presidents of the Royal College of Surgeons of Edinburgh.