James Currie was born in Dumfriesshire in 1756. Currie was apprenticed to be a factor in Virginia in 1771, returning to Britain in 1777. He studied in Edinburgh before receiving his MD in Glasgow in 1780. Currie opened a practice in Liverpool later that year. In 1786 Currie was appointed physician to the Liverpool Infirmary and was a co-founder of an asylum in the city in 1792. Currie was also an active campaigner against the slave trade. He died in Devon in 1805.

John Coakley Lettsom was born in 1744 in the West Indies. After returning to England, he was apprenticed to a surgeon and apothecary in 1761. He returned to the West Indies briefly in 1767, after his father's death, where he freed the enslaved people his father had bequeathed to him before going into medical practice in the Caribbean. Returning to Britain, he studied medicine at the University of Edinburgh before graduating MD at Leiden in 1769. Lettsom then set up practice in London and was the co-founded, in 1770, of the General Dispensary which gave free medical treatment to the poor. Subsequently, Lettsom was awarded fellowship of the Royal Society in 1773. Lettsom was also a co-founder of the Medical Society of London. He died in London in 1815.

Nicholas Bindon was of Irish descent and studied medicine at the University of Edinburgh. He enrolled in 1785 and received his MD on 12 September 1788. His dissertation was entitled 'Dissertation medica inauguralis, de ictero' and had jaundice as its subject matter. In 1791 he was made a Licentiate of the Royal College of Physicians of Edinburgh.

Thomas Arnold was born in Leicester. He was awarded MD at the University of Edinburgh in 1766. Arnold then returned to Leicester where he took over the management of his father's private lunatic asylum. In 1771 he took up the post of physician at the Leicester Infirmary and, in 1784, was appointed as the infirmary's senior physician. Arnold's most notable publication was 'Observations on the Nature, Kinds, Causes, and Prevention of Insanity, Lunacy, or Madness' (1782-1786). He died in 1816 in Leicester.

David Morton received an MD from King's College, Aberdeen, in 1768. He worked as a surgeon in Jamaica by 1783 and appears to have spent his career there, being regarded as a respected physician in Spanish Town. He may also have acted as a judge.

Thomas Stevenson received an MD from the University of St Andrews in 1786 and soon after became a Fellow of the Royal College of Physicians of Edinburgh. He practised in Arbroath and died in 1799.

Thomas Cochrane received an MD from the University of Glasgow in 1784. Having lived for many years on St Christopher (St Kitts and Nevis), he developed abolitionist sympathies and in 1789 presented a paper to the Edinburgh chapter of the Society for Effecting the Abolition of the Slave Trade. He later served as Inspector and Surgeon of Prisons in Liverpool and studied the eating habits of Charles Domery. He died about 1810.

Samuel Spalding received a degree from St Andrews in 1785 and became a Fellow of the Royal College of Physicians of Edinburgh in 1787. He appears to have practised in Devizes, Wiltshire, and may have been connected with the Spalding family of Holm House, Wigtownshire. He died about 1811.

George Bachmatieve was born in Moscow, the son of a revenue official. Under the tutelage of Andrei Samborsky, the agronomist and dean of Ascension Cathedral, Tsarskoye Selo, Bachmativeve travelled to Britain to continue his education. After studies in London he enrolled at the University of Edinburgh, receiving an MD in 1786 for a thesis on smallpox. Despite his adherence to the Brunonian school of medical thought, in contrast to the prevailing Cullenite idea, Bachmatieve became a Fellow of the Royal College of Physicians of Edinburgh and was President of the Natural History Society in 1785. He returned to Moscow in 1788, but died less than three months later.

Thomas Spens, the son of future President of this College Nathaniel Spens, was born in Edinburgh in 1764 and received an MD from the University of Edinburgh in 1784. Elected a Fellow in 1788, he practised with his father and held College offices including Librarian and President (1803-1806). He died in Edinburgh in 1842.