Distinct T-cell immunophenotypic signature in a subset of sarcoidosis patients with arthritis

Background: The objective of the study was to assess T-cell subsets in sarcoidosis patients with or without articular involvement.

Methods: Treatment-naïve patients were divided into Group A (articular) and Group B (non-articular) based on joint involvement. Flow cytometric analysis of T-cell subsets and pro-inflammatory cytokines were carried out in the peripheral blood.

Sezary syndrome: diagnosis and management

We describe a case of a delayed diagnosis of Sezary syndrome in a patient with longstanding generalised pruritus, erythroderma, alopecia and nail dystrophy. We highlight some of the difficulties in diagnosis despite the fact that all patients have a characteristic circulating malignant T-cell lymphocyte in peripheral blood. These cells with cerebriform nuclei should be sought in peripheral blood films and further evaluated using flow cytometry in all patients with an erythrodermatous presentation.