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1455 – Gutenberg prints the Bible
1492 – Christopher Columbus crosses the Atlantic
1497/1500 – Cuba, Johannes: Ortus sanitatis
1508 – Michelangelo begins painting the Sistine Chapel
1509 – King Henry VIII crowned
1516 – Dioscorides Pedanius: De medicinali material libri quinque
1517 – Reformation starts in Germany
1519 – Leonardo da Vinci dies
1530 - Brunfels, Otto: Herbarum vivae eicones
1551 – Turner, William: A newe herball
1552 – Bock, Hieronymus: De stirpium, maxime earum…
1552 – Egenolff, Christian: Herbarum, arborum, fructicum…
1555 – Trinity College in Oxford founded
1558 – Reign of Elizabeth I starts
1564 – Shakespeare and Galileo born
1572 – Mattioli, Pietro Andrea & Dioscorides Pedanius: Commentaires…
1576 – Titian dies
1577 – Francis Drake begins his voyage around the globe
1578 – William Harvey born
1587 – Mary Queen of Scots executed
1592 – Colonna, Fabio: Phytobasanos sive plantarum aliquot historia